Trogden KP, Battaglia RA, Kabiraj P, Madden VJ, Herrmann H, Snider NT. (2018). An image-based small molecule screen identifies vimentin as a pharmacologically relevant target of simvastatin in cancer cells. FASEB J. 32:5 1-14


Battaglia RA, Kabiraj P, Willcockson HH, Lian M, Snider NT. Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications. (2017). J Vis Exp. (123). doi: 10.3791/55655.


Snider NT (2016). Kidney keratins: cytoskeletal stress responders with biomarker potential.  Kidney International. 89(4):738-740.

Snider NT and Omary MB. (2016). Assays for post-translational modifications of intermediate filament proteins. Methods in Enzymology: Intermediate Filaments. 568:113-138.   

Snider NT, Walker VJ, Hollenberg PF. Assay of endocannabinoid oxidation by cytochrome P450. (2016). Methods in Molecular Biology: Endocannabinoid Signaling. 1412:227-236.

Snider NT, Portney DA, Willcockson HH, Maitra D, Martin HC, Greenson JK, and Omary MB. Ethanol and acetaminophen synergistically induce aggregation and TCH346-insensitive nuclear translocation of GAPDH (2016). PLoS One. 11(8):e0160982.


Snider NT, Altshuler PA, Omary MB. (2015). Modulation of cytoskeletal dynamics by mammalian nucleoside diphosphate kinase (NDPK) proteins. Naunyn Schmiedebergs Arch Pharmacol. 388(2):189-197.

Kwan R, Chen L, Looi K, Tao GZ, Weerasinghe SV, Snider NT, Conti MA, Adelstein RS, Xie Q, Omary MB. (2015) PKC412 normalizes mutation-related keratin filament disruption and hepatic injury in mice by promoting keratin-myosin binding. Hepatology 62:1858-1869.


Snider NT, Altshuler PJ, Wan S, Welling TH, Cavalcoli J, and Omary MB. (2014). Alternative splicing of human NT5E in cirrhosis and hepatocellular carcinoma produces a negative regulator of ecto-5'-nucleotidase (CD73). Mol Biol Cell. 25:4024-4033.

Snider NT and Omary MB. (2014). Post-translational modifications of intermediate filament proteins: function and regulation. Nat Rev Mol Cell Biol. 15:163-177.


Snider NT, Park H, Omary MB. (2013). A conserved rod domain phosphotyrosine that is targeted by the phosphatase PTP1B promotes keratin 8 insolubility and filament organization. J Biol Chem. 288:31329-31337. *JBC Paper of the Week

Snider NT, Griggs NW, Singla A, Moons DS, Weerasinghe SV, Lok AS, Ruan C, Burant CF, Conjeevaram HS, Omary MB. (2013). CD73 (ecto-5'-nucleotidase) hepatocyte levels differ across mouse strains and contribute to Mallory-Denk body formation. Hepatology 58:1790-1800.

Snider NT, Leonard JM, Kwan R, Griggs NW, Rui L, Omary MB. (2013). Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation. J Cell Biol. 200: 241-247.

Singla A, Griggs NW, Kwan R, Snider NT, Maitra D, Ernst SA, Herrmann H, Omary MB. (2013). Lamin aggregation is an early sensor of porphyria-induced liver injury. J Cell Sci. 126:3105-3112.


Singla A, Moons DS, Snider NT, Wagenmaker ER, Jayasundera VB, Omary MB. (2012). Oxidative stress, Nrf2 and keratin upregulation associate with Mallory-Denk body formation in mouse erythropoietic protoporphyria. Hepatology. 56: 322-331.


Snider NT,  Weerasinghe SV, Singla A, Leonard JM, Hanada S, Andrews PC, Lok AS, Omary MB. (2011). Energy determinants GAPDH and NDPK act as genetic modifiers for hepatocyte inclusion formation. J Cell Biol 195:217-229. **Highlighted in JCB [195: 166] and Hepatology [55: 2027-30]**

Snider NT, Weerasinghe SV, Iñiguez-Lluhí JA, Herrmann H, Omary MB. (2011). Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation. J Biol Chem. 286: 2273-2284.

Sridar C, Snider NT, Hollenberg PF. (2011). Anandamide oxidation by wild type and polymorphically expressed CYP2B6 and CYP2D6. Drug Metab Dispos. 39: 782-788.

Hong S, Zheng G, Wu X, Snider NT, Owyang C, Wiley JW. (2011). Corticosterone mediates reciprocal changes in CB1 and TRPV1 receptors in primary sensory neurons in the chronically stressed rat. Gastroenterology. 140: 627-637.


Hanada S†, Snider NT†, Brunt, EM, Hollenberg PF, Omary MB. (2010). Gender dimorphic formation of mouse Mallory-Denk bodies and the role of xenobiotic metabolism and oxidative stress. Gastroenterology. 138:1607-1617. †equal contribution.

Snider NT, Walker VJ, Hollenberg PF. (2010). Oxidation of the endogenous cannabinoid arachidonoyl ethanolamide by the cytochrome P450 monooxygenases: physiological and pharmacological implications. Pharmacol Rev. 62: 136-154.

Zhou Q, Snider NT, Liao J, Li DH, Hong A, Ku NO, Cartwright CA, Omary MB. (2010). Characterization of in vivo keratin 19 phosphorylation on tyrosine-391. PLoS One. 5(10):e13538.

Pratt-Hyatt M, Zhang H, Snider NT, Hollenberg PF. (2010). Effects of a commonly occurring genetic polymorphism of human CYP3A4 (Ile118Val) on the metabolism of anandamide. Drug Metab Dispos. 38: 2075-2082.


Snider NT, Nast JA, Tesmer LA, Hollenberg PF. (2009). A cytochrome P450-derived epoxygenated metabolite of anandamide is a potent cannabinoid receptor 2-selective agonist. Mol Pharmacol. 75: 965-972.

Snider NT, Sikora MJ, Sridar C, Feuerstein TJ, Rae JR, Hollenberg PF. (2008). The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6. J Pharmacol Exp Ther. 327: 538-545.

Snider NT, Kornilov AM, Kent UM, Hollenberg PF. (2007). Anandamide metabolism by human liver and kidney microsomal cytochrome P450 enzymes to form hydroxyeicosatetraenoic and epoxyeicosatrienoic acid ethanolamides. J Pharmacol Exp Ther. 321: 590-597.

Welcome to the snider lab

in the Cell Biology and Physiology Department at UNC-Chapel Hill