in the Cell Biology and Physiology Department at UNC-Chapel Hill
Selected work on intermediate filaments:
Snider NT and Omary MB. (2014).
Post-translational modifications of intermediate filament proteins: function and regulation.
Nat Rev Mol Cell Biol. 15:163-177.
Snider NT, Park H, Omary MB. (2013).
A conserved rod domain phosphotyrosine that is targeted by the phosphatase PTP1B promotes keratin 8 insolubility and filament organization.
J Biol Chem 288:31329-37. **JBC Paper of the Week**
Snider NT, Leonard JM, Kwan R, Griggs NW, Rui L, Omary MB. (2013).
Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation.
J Cell Biol. 200: 241-7.
Snider NT, Weerasinghe SV, Iñiguez-Lluhí JA, Herrmann H, Omary MB. (2011).
Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation.
J Biol Chem. 286: 2273-2284.
Selected work on liver disease mechanisms:
Snider NT, Altshuler PJ, Wan S, Welling TH, Cavalcoli J, and Omary MB. (2014).
Alternative splicing of human NT5E in cirrhosis and hepatocellular carcinoma produces a negative regulator of ecto-5'-nucleotidase (CD73).
Mol Biol Cell. E14-06-1167
Snider NT, Griggs NW, Singla A, Moons DS, Weerasinghe SV, Lok AS, Ruan C, Burant CF, Conjeevaram HS, Omary MB. (2013). CD73 (ecto-5'-nucleotidase) hepatocyte levels differ across mouse strains and contribute to Mallory-Denk body formation.
Snider NT, Weerasinghe SV, Singla A, Leonard JM, Hanada S, Andrews PC, Lok AS, Omary MB. (2011). Energy determinants GAPDH and NDPK act as genetic modifiers for hepatocyte inclusion formation.
J Cell Biol 195:217-29. **Highlighted in JCB [195: 166] and Hepatology [55: 2027-30]
Hanada S†, SniderNT†, Brunt, EM, Hollenberg PF, Omary MB. (2010).
Gender dimorphic formation of mouse Mallory-Denk bodies and the role of xenobiotic metabolism and oxidative stress.
Gastroenterology. 138:1607-17. †equal contribution.