Welcome to the snider lab

in the Cell Biology and Physiology Department at UNC-Chapel Hill

Selected work on intermediate filaments:

Snider NT and Omary MB. (2014).

Post-translational modifications of intermediate filament proteins: function and regulation.

Nat Rev Mol Cell Biol. 15:163-177.

Snider NT, Park H, Omary MB. (2013).

A conserved rod domain phosphotyrosine that is targeted by the phosphatase PTP1B promotes keratin 8 insolubility and filament organization.

J Biol Chem 288:31329-37.  **JBC Paper of the Week**

Snider NT, Leonard JM, Kwan R, Griggs NW, Rui L, Omary MB. (2013).

Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation.

J Cell Biol. 200: 241-7.

Snider NT, Weerasinghe SV, Iñiguez-Lluhí JA, Herrmann H, Omary MB. (2011).

Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation.

J Biol Chem. 286: 2273-2284.

Selected work on liver disease mechanisms:

Snider NT, Altshuler PJ, Wan S, Welling TH, Cavalcoli J, and Omary MB. (2014).

Alternative splicing of human NT5E in cirrhosis and hepatocellular carcinoma produces a negative regulator of ecto-5'-nucleotidase (CD73).

Mol Biol Cell. E14-06-1167

Snider NT, Griggs NW, Singla A, Moons DS, Weerasinghe SV, Lok AS, Ruan C, Burant CF, Conjeevaram HS, Omary MB. (2013). CD73 (ecto-5'-nucleotidase) hepatocyte levels differ across mouse strains and contribute to Mallory-Denk body formation.

Hepatology 58:1790-1800.

Snider NT,  Weerasinghe SV, Singla A, Leonard JM, Hanada S, Andrews PC, Lok AS, Omary MB. (2011). Energy determinants GAPDH and NDPK act as genetic modifiers for hepatocyte inclusion formation.

J Cell Biol 195:217-29.  **Highlighted in JCB [195: 166] and Hepatology [55: 2027-30]

Hanada S, SniderNT†, Brunt, EM, Hollenberg PF, Omary MB. (2010).

Gender dimorphic formation of mouse Mallory-Denk bodies and the role of xenobiotic metabolism and oxidative stress.

Gastroenterology. 138:1607-17. †equal contribution.